澳门六合彩开奖记录
BI3BR7: Structural Proteomics
Module code: BI3BR7
Module provider: School of Biological Sciences
Credits: 10
Level: Level 3 (Honours)
When you'll be taught: Semester 1
Module convenor: Professor Kimberly Watson, email: k.a.watson@reading.ac.uk
Pre-requisite module(s): BEFORE TAKING THIS MODULE YOU MUST TAKE BI2BL5 (Compulsory)
Co-requisite module(s):
Pre-requisite or Co-requisite module(s):
Module(s) excluded:
Placement information: NA
Academic year: 2024/5
Available to visiting students: No
Talis reading list: Yes
Last updated: 21 May 2024
Overview
Module aims and purpose
This module will build upon the foundations of 3-dimensional protein structure and how 鈥渇unction follows form鈥, laid in the Protein Structure Function module (BI2BL5). Without doubt, Structural 鈥渙mics鈥 efforts have had an enormous impact on structural databases, but importantly, these efforts equally have had huge technological impact that has altered the way structural biologists and protein biochemists work. The role that Structural Proteomics has played in the first part of the 21st century is equivalent to that played by the Human Genome project in the last part of the 20th century. This module will provide an historical and up-to-date overview of the Structural Proteomics field and its impact on Life Science research.
The module aims:
- To gain fundamental and detailed knowledge of the field of Structural Proteomics for Life Science research
- To gain an appreciation for the technological advances developed and used in Structural Proteomics research
- To understand the principles of modern biophysical and bioanalytical techniques to unravel protein structure and function
- To develop an understanding of the importance of multidisciplinary approaches used to elucidate molecular details of protein structure and function
- To gain experience of using computational tools and Web servers to investigate protein structure and function of an unknown protein
- To gain an appreciation of how to unravel detailed molecular mechanisms using integrated Structural Proteomics techniques
Module learning outcomes
By the end of the module, it is expected that students will be able to:
- Describe the impact of Structural Proteomics on macromolecular databases
- Outline the advances in high throughput technologies arising from Structural Proteomics and describe their impact on life science research
- Explain the importance of target selection strategies and describe the role of bioinformatics and biochemical methods to guide target selection
- Discuss protein engineering approaches for protein structure-function research and outline methods for separation and identification of protein targets
- Explain the principles of various biophysical methods (for example, X-ray crystallography, NMR spectroscopy, Mass spectrometry, Circular Dichroism Spectroscopy, Small Angle X-ray Scattering, cryo- Electron Microscopy) to elucidate molecular details of protein structure and function
- Using examples, discuss the impact of Structural Proteomics on drug design
Module content
Teaching will be through a series of 14 lectures with 2 supporting practicals. The lectures will provide a detailed overview of the field of Structural Proteomics for Life Science research and provide a theoretical overview of the various biophysical methods to elucidate the molecular details of protein structure and function.聽
The practicals will be computer based and provide experience of using computational tools and Web servers to investigate protein structure and function of an unknown protein.聽
Structure
Teaching and learning methods
- Most weeks will include two ~45-minute lectures.聽
- Two computer based practical classes.聽
Study hours
At least 25 hours of scheduled teaching and learning activities will be delivered in person, with the remaining hours for scheduled and self-scheduled teaching and learning activities delivered either in person or online. You will receive further details about how these hours will be delivered before the start of the module.
聽Scheduled teaching and learning activities | 聽Semester 1 | 聽Semester 2 | 听厂耻尘尘别谤 |
---|---|---|---|
Lectures | 14 | ||
Seminars | |||
Tutorials | |||
Project Supervision | |||
Demonstrations | |||
Practical classes and workshops | 6 | ||
Supervised time in studio / workshop | |||
Scheduled revision sessions | |||
Feedback meetings with staff | |||
Fieldwork | |||
External visits | 5 | ||
Work-based learning | |||
聽Self-scheduled teaching and learning activities | 聽Semester 1 | 聽Semester 2 | 听厂耻尘尘别谤 |
---|---|---|---|
Directed viewing of video materials/screencasts | |||
Participation in discussion boards/other discussions | |||
Feedback meetings with staff | |||
Other | |||
Other (details) | |||
聽Placement and study abroad | 聽Semester 1 | 聽Semester 2 | 听厂耻尘尘别谤 |
---|---|---|---|
Placement | |||
Study abroad | |||
聽Independent study hours | 聽Semester 1 | 聽Semester 2 | 听厂耻尘尘别谤 |
---|---|---|---|
Independent study hours | 75 |
Please note the independent study hours above are notional numbers of hours; each student will approach studying in different ways. We would advise you to reflect on your learning and the number of hours you are allocating to these tasks.
Semester 1 The hours in this column may include hours during the Christmas holiday period.
Semester 2 The hours in this column may include hours during the Easter holiday period.
Summer The hours in this column will take place during the summer holidays and may be at the start and/or end of the module.
Assessment
Requirements for a pass
Students need to achieve an overall module mark of 40% to pass this module.
Summative assessment
Type of assessment | Detail of assessment | % contribution towards module mark | Size of assessment | Submission date | Additional information |
---|---|---|---|---|---|
Written coursework assignment | Essay | 40 | Semester 1 | ||
Set exercise | Practical report | 50 | Semester 1 | ||
In-class test administered by School/Dept | Blackboard test | 10 | Semester 1 |
Penalties for late submission of summative assessment
The Support Centres will apply the following penalties for work submitted late:
Assessments with numerical marks
- where the piece of work is submitted after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for that piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of three working days;
- the mark awarded due to the imposition of the penalty shall not fall below the threshold pass mark, namely 40% in the case of modules at Levels 4-6 (i.e. undergraduate modules for Parts 1-3) and 50% in the case of Level 7 modules offered as part of an Integrated Masters or taught postgraduate degree programme;
- where the piece of work is awarded a mark below the threshold pass mark prior to any penalty being imposed, and is submitted up to three working days after the original deadline (or any formally agreed extension to the deadline), no penalty shall be imposed;
- where the piece of work is submitted more than three working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.
Assessments marked Pass/Fail
- where the piece of work is submitted within three working days of the deadline (or any formally agreed extension of the deadline): no penalty will be applied;
- where the piece of work is submitted more than three working days after the original deadline (or any formally agreed extension of the deadline): a grade of Fail will be awarded.
The University policy statement on penalties for late submission can be found at: /cqsd/-/media/project/functions/cqsd/documents/qap/penaltiesforlatesubmission.pdf
You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.
Formative assessment
Formative assessment is any task or activity which creates feedback (or feedforward) for you about your learning, but which does not contribute towards your overall module mark.
Reassessment
Type of reassessment | Detail of reassessment | % contribution towards module mark | Size of reassessment | Submission date | Additional information |
---|---|---|---|---|---|
Written coursework assignment | Essay | 40 | During the University resit period | ||
Set exercise | Practical report | 50 | During the University resit period | ||
In-class test administered by School/Dept | Blackboard test | 10 | During the University resit period |
Additional costs
Item | Additional information | Cost |
---|---|---|
Computers and devices with a particular specification | ||
Printing and binding | ||
Required textbooks | ||
Specialist clothing, footwear, or headgear | ||
Specialist equipment or materials | ||
Travel, accommodation, and subsistence |
THE INFORMATION CONTAINED IN THIS MODULE DESCRIPTION DOES NOT FORM ANY PART OF A STUDENT'S CONTRACT.