BI3BE8: Cardiovascular Disease

Module code: BI3BE8

Module provider: School of Biological Sciences

Credits: 10

Level: Level 3 (Honours)

When you'll be taught: Semester 2

Module convenor: Professor David Leake, email: d.s.leake@reading.ac.uk

Pre-requisite module(s): BEFORE TAKING THIS MODULE YOU MUST TAKE BI1BEC1 (Compulsory)

Co-requisite module(s):

Pre-requisite or Co-requisite module(s):

Module(s) excluded:

Placement information: NA

Academic year: 2024/5

Available to visiting students: Yes

Talis reading list: No

Last updated: 21 May 2024

Overview

Module aims and purpose

The world’s leading cause of death is cardiovascular disease, mainly coronary heart disease and strokes. The underlying cause is most often atherosclerosis, in which cholesterol is laid down in inflamed arteries. This leads to thrombosis (clotting) and heart attacks and thrombotic strokes, which very sadly are often fatal. In this module, you will learn the latest insights into the causes of heart attacks and strokes and how drugs, including cholesterol-lowering statins, can be used to treat it. The mechanisms by which the heart muscle is damaged by a heart attack and can lead to fatal arrhythmias and heart failure will be discussed. You will also discover how cardiovascular disease is affected by our genetic makeup and how it can be lessened by changes to our lifestyle and diet.Ìý

Module learning outcomes

By the end of the module, it is expected that students will be able to:

1. Describe the detailed anatomy and physiology of the cardiovascular system, including angiogenesis, lymphangiogenesis and ageing
2. Discuss the current theories for the pathogenesis of atherosclerosis
3. Recognise the importance of thrombosis in coronary heart disease and thrombotic strokes and describe the biochemical mechanisms by which drugs act to prevent or treat thrombosis
4. ÌýDiscuss the causes and treatments of strokes, cardiac arrhythmias and heart failure and discuss the main risk factors, including genes and diet, for cardiovascular disease and the mechanisms by which they act

Module content

Lecture material includes the following topics:

• The anatomy and physiology of the cardiovascular system, including angiogenesis, lymphangiogenesis and ageing
• The worldwide medical importance of coronary heart disease and strokes is discussed
• The latest theories for the pathogenesis of atherosclerosis are discussed, followed by the mechanisms that lead to thrombosis, strokes, myocardial infarctions, cardiac arrhythmias and heart failure
• The pharmacological treatment of cardiovascular disease is described in terms of lipid-lowering drugs, antithrombotic drugs and drugs to treat arrhythmias and heart failure
• The risk factors, including hypercholesterolaemia (sporadic and familial), hypertension, smoking, diabetes, obesity, genes and diet, for coronary heart disease and strokes are discussed, together with their mechanisms of action

There will also be lectures by a clinician on the therapies for cardiovascular diseases.

Structure

Teaching and learning methods

The learning outcomes will be met through a mixture of lectures, self-directed learning and directed independent study. Appropriate supplementary information and reading lists will be provided on Blackboard.Ìý

Study hours

At least 22 hours of scheduled teaching and learning activities will be delivered in person, with the remaining hours for scheduled and self-scheduled teaching and learning activities delivered either in person or online. You will receive further details about how these hours will be delivered before the start of the module.

Please note the independent study hours above are notional numbers of hours; each student will approach studying in different ways. We would advise you to reflect on your learning and the number of hours you are allocating to these tasks.

Semester 1 The hours in this column may include hours during the Christmas holiday period.

Semester 2 The hours in this column may include hours during the Easter holiday period.

Summer The hours in this column will take place during the summer holidays and may be at the start and/or end of the module.

Assessment

Requirements for a pass

Students need to achieve an overall module mark of 40% to pass this module.

Summative assessment

Penalties for late submission of summative assessment

The Support Centres will apply the following penalties for work submitted late:

Assessments with numerical marks

• where the piece of work is submitted after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for that piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of three working days;
• the mark awarded due to the imposition of the penalty shall not fall below the threshold pass mark, namely 40% in the case of modules at Levels 4-6 (i.e. undergraduate modules for Parts 1-3) and 50% in the case of Level 7 modules offered as part of an Integrated Masters or taught postgraduate degree programme;
• where the piece of work is awarded a mark below the threshold pass mark prior to any penalty being imposed, and is submitted up to three working days after the original deadline (or any formally agreed extension to the deadline), no penalty shall be imposed;
• where the piece of work is submitted more than three working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

Assessments marked Pass/Fail

• where the piece of work is submitted within three working days of the deadline (or any formally agreed extension of the deadline): no penalty will be applied;
• where the piece of work is submitted more than three working days after the original deadline (or any formally agreed extension of the deadline): a grade of Fail will be awarded.

The University policy statement on penalties for late submission can be found at: /cqsd/-/media/project/functions/cqsd/documents/qap/penaltiesforlatesubmission.pdf

You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

Formative assessment

Formative assessment is any task or activity which creates feedback (or feedforward) for you about your learning, but which does not contribute towards your overall module mark.

Immediate structured anonymous peer feedback is given on the individual student talks, followed later by individual feedback with suggestions for improvement by an academic member of staffÌý

Reassessment

Additional costs