CH4O1-Advanced Organic Chemistry - Synthesis of Complex Targets (2)

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Level:7
Terms in which taught: Autumn term module
Pre-requisites:
Non-modular pre-requisites:
Co-requisites:
Modules excluded:
Current from: 2023/4

Module Convenor: Dr Chris Smith
Email: c.d.smith@reading.ac.uk

Module Co-convenor: Dr James Cooper
Email: james.cooper@reading.ac.uk

Type of module:

Summary module description:

Learn the most up-to-date techniques for controlling chirality in the synthesis of complex molecular targets and study the chemistry of heterocycles with more than one heteroatom. Both topics build on the basics of organic chemistry that you have learnt during the first three years of your degree. This course should be useful to Ìýanyone planning to pursue a chemistry-related career in the future.

Aims:
The course will provide the student with the tools required to approach the synthesis of complex molecular targets, in particular the student will be introduced to enantioselective synthesis, multi-step synthesis and the chemistry of heterocycles which incorporate more than one heteroatom.

Assessable learning outcomes:

Students who have successfully completed this module will be able to:

• Describe the processes through which one enantiomer of a given molecular target may be synthesised.


• Be able to explain and apply selected methods of asymmetric synthesis to unseen synthetic problems.


• Describe the synthesis and properties of heterocyclic compounds and apply the knowledge to aid an understanding of their role in biological systems.

Additional outcomes:

Outline content:

The Elements of Asymmetric Synthesis. This course will examine the general principles underlying asymmetric synthesis. In particular we will examine the need to generate diastereoisomeric transition states in order to achieve asymmetric induction. We will examine the relative merits of chiral auxiliaries and chiral catalysts then exemplify these with reactions of great synthetic significance, e.g. the Evans enolate alkylation. (10 lectures)

Advanced Heterocyclic Chemistry(5 hours). Chemistry and synthesis of complex heteroaromatics: pyridazines, pyrazines, pyrimidines, imidazoles, thiazoles and oxazoles. Complex heteroaromatics in Nature.

Brief description of teaching and learning methods:
Two one hour lectures per week with approximately one tutorial or workshop on related material every three weeks.

Contact hours:

Ìý	Autumn	Spring	Summer
Lectures	15
Seminars			3
Tutorials	3
Guided independent study:	79
Ìý	Ìý	Ìý	Ìý
Total hours by term	97	0	3
Ìý	Ìý	Ìý	Ìý
Total hours for module	100

Summative Assessment Methods:

Method	Percentage
Written exam	100

Summative assessment- Examinations:

1.5 hours.

The examination for this module will require a narrowly defined time window and is likely to be held in a dedicated exam venue.

Summative assessment- Coursework and in-class tests:

Formative assessment methods:

Students will attend tutorials on the material covered in this module and receive feedback on their performance. Attendance is compulsory. Tutorials to be submitted as detailed on Blackboard.

Penalties for late submission:

The Support Centres will apply the following penalties for work submitted late:

• where the piece of work is submitted after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for that piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of five working days;
• where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

The University policy statement on penalties for late submission can be found at: /cqsd/-/media/project/functions/cqsd/documents/cqsd-old-site-documents/penaltiesforlatesubmission.pdf
You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

Assessment requirements for a pass:
An overall mark of 50%.

Reassessment arrangements:

Reassessment of the written examination (100%) is heldÌýduring the University administered re-examination period in August

Final year students are not eligible to resit this module unless they have failed their degree programme overall.

Additional Costs (specified where applicable):

1) Required text books:Ìý None

2) Specialist equipment or materials:Ìý None

3) Specialist clothing, footwear or headgear:Ìý None

4) Printing and binding:Ìý None

5) Computers and devices with a particular specification:Ìý None

6) Travel, accommodation and subsistence:Ìý None

Last updated: 30 March 2023